
Tender strands of spaghetti intertwine with succulent chicken and crisp vegetables in a savory-sweet sauce that transforms simple ingredients into an irresistible meal. This Chicken Spaghetti Lo Mein brings the authentic flavors of your favorite takeout to your kitchen with minimal effort, creating a satisfying dish that bridges comfort food and culinary adventure.
After experimenting with countless homemade Asian-inspired recipes, this lo mein variation has become my family's most requested dinner. My husband, who typically orders lo mein whenever we get takeout, now prefers this homemade version, claiming the freshness of the vegetables and perfectly cooked noodles make all the difference.
Kitchen Essentials
- Spaghetti Noodles: Regular spaghetti creates the perfect texture and absorbs sauce beautifully.
- Chicken Breast: Select plump, uniform pieces for even cooking and tender results.
- Bell Peppers: Choose brightly colored peppers for visual appeal and sweet flavor.
- Soy Sauce: Use low-sodium varieties to control the saltiness of your final dish.
- Hoisin Sauce: This thick, fragrant sauce provides the distinctive sweet-savory base.
Creating Perfect Lo Mein
- Noodle Mastery:
- Begin by cooking your spaghetti just until al dente, then immediately rinse under cold water to stop the cooking process. This prevents the noodles from becoming soggy when tossed with the hot sauce.
- Protein Preparation:
- Slice your chicken into thin, uniform strips that will cook quickly and evenly. Season lightly with salt and pepper before cooking to build layers of flavor throughout the dish.
- Vegetable Harmony:
- Maintain consistent sizes when cutting your vegetables to ensure they cook evenly. The perfect stir-fry requires vegetables that retain their crispness while becoming tender enough to blend with the other ingredients.
- Sauce Symphony:
- Whisk your sauce ingredients together before adding to the pan, ensuring the flavors blend perfectly. The combination of soy sauce, hoisin, and a touch of sesame oil creates the authentic flavor that defines great lo mein.

The first time I made this recipe, I was trying to recreate my grandmother's version that she learned while living in Hong Kong. Her trick was always to toast the garlic briefly before adding other ingredients, claiming it released the essential oils that gave the dish its characteristic aroma.
Perfect Pairings
Serve this vibrant lo mein with crispy vegetable spring rolls and a refreshing cucumber salad dressed with rice vinegar and sesame oil. For a complete feast, add steamed dumplings on the side.
Creative Variations
Transform this dish by substituting shrimp for chicken, or create a vegetarian version with meaty mushrooms and extra vegetables. For a spicier experience, add sriracha or chili oil to the sauce.
Storage Solutions
Store leftover lo mein in an airtight container for up to three days. When reheating, add a splash of water or chicken broth to revive the sauce's consistency and prevent dryness.
After preparing this dish countless times for family dinners and potluck gatherings, I've found that the true joy of Chicken Spaghetti Lo Mein lies in its adaptability. Whether you follow the recipe exactly or customize it with whatever vegetables are in your refrigerator, the result is always a comforting, satisfying meal that brings people together around the table.

Frequently Asked Questions
- → Can I use other pasta instead of spaghetti?
- Yes! Regular lo mein noodles, linguine, or fettuccine all work well in this recipe.
- → Is there a substitute for oyster sauce?
- Try hoisin sauce with a splash of Worcestershire, or additional soy sauce with a pinch of sugar.
- → Can I make this ahead of time?
- Yes, it keeps well in the fridge for 3-4 days. Reheat in a skillet with a splash of water.
- → What vegetables work best?
- Bell peppers, carrots, broccoli, snow peas, and mushrooms all work great. Use what you have!
- → How can I make this gluten-free?
- Use gluten-free spaghetti and tamari instead of regular soy sauce.